Hundreds of nanosecond aMD simulations are enough to capture millisecond time scale events of unbiased MD simulations.
For instance, some reports have proved that 100 ns aMD simulations can give the same simulation results as that obtained from more than
10 ms unbiased MD simulations based on the crystal structure of GPCRs.
~Computational study on the interaction between CCR5 and HIV-1 entry inhibitor maraviroc: insight from accelerated molecular dynamics simulation and free energy calculation~